(4Z)-Lachnophyllum Lactone, an Acetylenic Furanone from Conyza bonariensis, Identified for the First Time with Allelopathic Activity against Cuscuta campestris

Cuscuta species are obligate parasitic plants that infect the stems of a wide range hosts including many crop and weed causing severe agricultural problems. Using in vitro experiments to screen organic extracts prepared from fifteen autotrophic found fields infested with campestris, we have identified for first time strong phytotoxic activity Conyza bonariensis extract against C. campestris. Additional pot revealed seven day-old seedlings had reduced capacity coil properly attach on plants, leading infection. Via activity-guided fractionation extracts, isolated acetylenic furanone (4Z)-lachnophyllum lactone as major active component, concentration required achieve reduction 50% seedling growth (IC50) 24.8 µg/mL. The discovery bioactivity could aid development efficient sustainable management strategies whose control is limited or non-existent.